Description
Overview of NadGo™ Vitality Blend
NadGo™ Vitality Blend is built around a single idea that runs through the longevity literature: antioxidant capacity, NAD+ availability and sirtuin activity are studied as interdependent processes rather than separate ones. The NMN component sits upstream of NAD+ on the salvage pathway, which is the point of difference from the direct NAD+ version of this formulation. Whether an upstream precursor reaches tissue more effectively than the coenzyme itself remains an open scientific question.
What Is In The Blend
Glutathione (500mg)
A tripeptide described across the literature as the principal intracellular thiol antioxidant and a determinant of cellular redox state.
NMN (500mg)
Nicotinamide mononucleotide, studied as a NAD+ precursor that enters the salvage pathway downstream of the NAMPT step.
Resveratrol (500mg)
A polyphenol researched for sirtuin modulating activity, with the field still divided on whether it acts on sirtuins directly or by way of AMPK.
Mechanism of Action
The three components are studied on connected but distinct pathways. Glutathione is characterised as the primary intracellular thiol antioxidant and a regulator of cellular redox potential. NMN is researched as a NAD+ precursor entering the salvage pathway downstream of NAMPT. Resveratrol is examined as a sirtuin modulating polyphenol, although whether that modulation is direct or indirect by way of AMPK is still debated.
The proposed link between the three is the sirtuin enzyme family, which uses NAD+ as a substrate. That relationship, rather than any single molecule, is the reason these three are studied side by side.
Why This Blend Is Researched
- Investigation of NAD+ precursor pathways and salvage pathway flux
- Study of intracellular redox balance and oxidative stress models
- Research into sirtuin signalling and its dependence on NAD+ as a substrate
- Examination of exogenous glutathione delivery, where effectiveness is still discussed
- Comparison of upstream precursor supply against direct coenzyme supply
In the research literature
The molecules in NadGo™ Vitality Blend each appear across published work in redox biology, NAD+ metabolism and sirtuin research. These are descriptions of independent research fields, not claims about this product.
Areas of Research Interest
NAD+ Precursor Supply
NMN is studied for its position on the salvage pathway and what that means for NAD+ availability in experimental models.
Redox and Oxidative Stress
Glutathione is examined as a determinant of cellular redox state and a reference point in oxidative stress work.
Sirtuin Signalling
Sirtuin enzymes consume NAD+ as substrate, which places them at the centre of the rationale for this combination.
Resveratrol Mechanism
Studied as a sirtuin modulating polyphenol, with the mechanism contested between direct activation and indirect action by way of AMPK.
Combination Evidence
No published research examines this specific three way combination, so the literature sits with the individual components.
Delivery and Availability
Exogenous delivery of both glutathione and NAD+ precursors remains an active point of discussion in the literature.
What The Research Has Shown
Each component carries its own separate body of published work, and the maturity of that work differs from one molecule to the next.
NMN has an extensive rodent literature alongside smaller human trials reporting raised NAD+ levels. Glutathione biochemistry is comparatively settled, with the open questions sitting around how effectively it is delivered from outside the cell. Resveratrol is the most contested of the three, with later work questioning whether sirtuin activation is direct. What ties them together is that sirtuin activity depends on NAD+ as a substrate, which is the stated rationale for combining them.
No published research examines this specific three way combination. Anyone working with it is looking at three individually studied molecules supplied together, not at a formulation with a literature of its own.
These are observations drawn from laboratory research settings, not approved medical, cosmetic or therapeutic claims. The information is provided for analytical reference only and is not guidance for use.
Composition and Suggested Measures
Each NadGo™ Vitality Blend pen holds 1500 mg of total active content across 3 ml, giving a combined concentration of 500 mg/ml. The figures below reflect commonly reported research handling measures and are provided for reference only.
Pen Composition (3 ml)
- Glutathione: 500 mg
- NMN: 500 mg
- Resveratrol: 500 mg
- Total active: 1500 mg
Per Unit (1 unit = 0.01 ml)
- 300 units per 3 ml pen
- Glutathione: approx 1.67 mg
- NMN: approx 1.67 mg
- Resveratrol: approx 1.67 mg
- Total blend: approx 5 mg
Setting The Quantity
- Turn the dial until the required number of increments is selected.
- Rotate clockwise to increase the quantity.
- Rotate counter-clockwise to decrease the quantity.
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